Description
GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS.{46949,46950} They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: α1-6, β1-4, γ1-3, δ, ε, π, θ, and ρ1-3, arranged around a central pore. Phasic inhibitory synaptic transmission is regulated by α1β2γ2 subunit-containing GABAA receptors, the major isoform found in the brain.{46950,46951} The β subunit of GABAA receptors interfaces with an α subunit to form the GABA binding site that initiates GABA-induced action potentials and forms the benzodiazepine binding site with the γ subunit. β3 subunit-containing GABAA receptors are widely expressed in the cerebral cortex, cerebellum, olfactory bulb, and hippocampus.{55098} Phosphorylation of the β3 subunit by PKA or PKC inhibits binding of the β3 subunit with the clathrin adaptor protein AP2 and reduces GABAA receptor endocytosis.{55097} Mutations in GABRB3, which encodes the β3 subunit isoform, have been found in patients with childhood absence epilepsy (CAE), infantile spasms (IS), and Lennox-Gastaut syndrome (LGS).{46950} Cayman’s GABAA Receptor β3 Subunit Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes the GABAA receptor β3 subunit at approximately 53 kDa from rat and mouse samples.
Synonyms: GABRB3|Gamma-aminobutyric Acid Receptor Subunit β3
Immunogen: Fusion protein from the cytoplasmic loop of the β3 subunit of the rat GABAA receptor
Formulation: 100 µl of Affinity-purified rabbit polyclonal antibody
Isotype:
Applications: IHC, WB
Origin:
Stability: 365 days
Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Neuroscience|Seizure Disorders
