Description
GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS.{46949,46950} They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: α1-6, β1-4, γ1-3, δ, ε, π, θ, and ρ1-3, arranged around a central pore. Phasic inhibitory synaptic transmission is regulated by α1β2γ2 subunit-containing GABAA receptors, the major isoform found in the brain.{46950,46951} The α subunit of GABAA receptors interfaces with a β subunit to form the GABA binding site that initiates GABA-induced action potentials and forms the benzodiazepine binding site with the γ subunit. Approximately 5% of all GABAA receptors contain α5 subunits and up to 25% of these receptors are expressed in the hippocampus, a region of the brain associated with learning and memory.{55095} Deletions in GABRA5, which encodes the α5 subunit isoform, have been found on chromosome 15 in patients with Angelman syndrome who typically develop autism spectrum disorder (ASD). Levels of α5 subunit-containing GABAA receptors are decreased in postmortem hippocampal samples from patients with advanced Alzheimer’s disease, Down syndrome, or fetal alcohol syndrome. Cayman’s GABAA Receptor α5 Subunit Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes the GABAA receptor α5 subunit at approximately 55 kDa from mouse and rat samples.
Synonyms: GABAA Receptor Subunit α5|GABRA5|γ-Aminobutyric Acid Receptor Subunit α5
Immunogen: Fusion protein from the cytoplasmic loop of the α5 subunit of the rat GABAA receptor
Formulation: 100 µl of Affinity-purified rabbit polyclonal antibody
Isotype:
Applications: IHC and WB
Origin:
Stability: 365 days
Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease
