A cell-permeable dipeptide that potently antagonizes PPARγ (Kd = 8.34 µM); reversibly and competitively blocks activation of PPARγ by rosiglitazone (IC50 = 8-32 µM); active in vivo

G3335 – 10 mg

Brand:
Cayman
CAS:
36099-95-3
Storage:
-20
UN-No:
Non-Hazardous - /

Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor with key roles in adipocyte differentiation and glucose homeostasis.{18294,14553} G3335 is a cell-permeable dipeptide that potently antagonizes PPARγ (Kd = 8.34 µM).{28551} It reversibly and competitively blocks activation of PPARγ by rosiglitazone (IC50 = 8-32 µM).{28551} G3335 is active in vivo, abolishing the protective effects of rosiglitazone in experimental spinal cord injury in rats.{28550} G3335 has also been used to evaluate the role of PPARγ in neurotoxicity studies.{28549,28552}  

 

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Description

A cell-permeable dipeptide that potently antagonizes PPARγ (Kd = 8.34 µM); reversibly and competitively blocks activation of PPARγ by rosiglitazone (IC50 = 8-32 µM); active in vivo, abolishing the protective effects of rosiglitazone in experimental spinal cord injury in rats

Formal name: L-tryptophyl-L-glutamic acid

Synonyms: 

Molecular weight: 333.3

CAS: 36099-95-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience

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