An allosteric ligand of Fz4; inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride; impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells

FzM1 – 5 mg

Brand:
Cayman
CAS:
1680196-54-6
Storage:
-20
UN-No:
Non-Hazardous - /

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4.{30790} At 10 µM, it inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway.{30790} FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells.{30790}  

 

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Description

An allosteric ligand of Fz4; inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride; impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells

Formal name: N-​[3-​hydroxy-​5-​(2-​thienyl)​phenyl]​-​N’-​2-​naphthalenyl-urea

Synonyms:  Frizzled M1

Molecular weight: 360.4

CAS: 1680196-54-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Signaling|Wnt Signaling||Research Area|Cell Biology|Cell Signaling|Wnt Signaling||Research Area|Neuroscience

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