A fusidane antibiotic; active against a variety of Gram-positive bacteria (MIC50s = 0.01-20 µg/ml) but not Gram-negative bacteria or fungi (MIC50s = >100 µg/ml for all); inhibits EF-G-mediated ribosomal recycling and protein translocation in isolated E. coli ribosomes (IC50s = ~0.1 and ~200 µM

Fusidic Acid (sodium salt) – 250 mg

Brand:
Cayman
CAS:
751-94-0
Storage:
-20
UN-No:
Non-Hazardous - /

Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum.{54000} It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani (MIC50s = 0.01-20 µg/ml) but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans and A. fumigatus (MIC50s = >100 µg/ml for all).{54001} Fusidic acid inhibits ribosomal recycling and protein translocation, processes mediated by elongation factor G (EF-G), in isolated E. coli ribosomes (IC50s = ~0.1 and ~200 µM, respectively).{54002} Topical administration of fusidic acid (2%) reduces the number of skin colony forming units (CFUs) and levels of TNF-α and IL-6 in a mouse model of methicillin-resistant S. aureus (MRSA) skin wound infection.{54003}  

 

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Description

A fusidane antibiotic; active against a variety of Gram-positive bacteria (MIC50s = 0.01-20 µg/ml) but not Gram-negative bacteria or fungi (MIC50s = >100 µg/ml for all); inhibits EF-G-mediated ribosomal recycling and protein translocation in isolated E. coli ribosomes (IC50s = ~0.1 and ~200 µM, respectively); reduces the number of skin CFUs and levels of TNF-α and IL-6 in a mouse model of MRSA skin wound infection

Formal name: (4α,8α,9β,13α,14β)-16β-(acetyloxy)- 3α,11α-dihydroxy-29-nordammara-17Z(20),24-dien-21-oic acid, monosodium salt

Synonyms:  SQ 16,360

Molecular weight: 538.7

CAS: 751-94-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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