A loop diuretic and an inhibitor of NKCC1 and NKCC2 (Kis = ~10 µM for both); increases diuresis in beagle dogs at 0.1 mg/kg; reduces ventricular collagen deposition and fibrosis in a rat model of dilated cardiomyopathy at 30 mg/kg

Furosemide – 5 g

Brand:
Cayman
CAS:
54-31-9
Storage:
-20
UN-No:
Non-Hazardous - /

Furosemide is a loop diuretic and an inhibitor of the Na+/K+/2Cl- (NKCC) cotransporters, NKCC1 and NKCC2 (Kis = ~10 µM for both).{23244,28297} In vivo, furosemide (0.1 mg/kg, p.o.) increases diuresis in beagle dogs.{52809} Furosemide (30 mg/kg) reduces ventricular collagen deposition and fibrosis in a rat model of dilated cardiomyopathy.{52810} It is also an inhibitor of carbonic anhydrase I (CAI), CAII, and CAIII (Kis = 0.052-0.065 µM) and organic ion transporter 1 (OAT1; Ki = 9.5 µM), as well as a GABAA receptor antagonist.{23242,29296,29298} This product is also available as an analytical reference standard (Item No. 26298).  

 

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Description

A loop diuretic and an inhibitor of NKCC1 and NKCC2 (Kis = ~10 µM for both); increases diuresis in beagle dogs at 0.1 mg/kg; reduces ventricular collagen deposition and fibrosis in a rat model of dilated cardiomyopathy at 30 mg/kg

Formal name: 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]-benzoic acid

Synonyms:  Frusemide

Molecular weight: 330.7

CAS: 54-31-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Small Molecule Inhibitors|Carbonic Anhydrase||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Cardiovascular Diseases|Cardiomyopathy||Research Area|Cardiovascular System|Heart||Research Area|Cardiovascular System|Kidney & Renal Disease

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