A phenalenone that inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 μM); less cytotoxic to HPB-M(a) cells (IC50 = 87 μM); selectively inhibits MMP-1 (IC50 = 170 μM) over MMP-2 and MMP-9 with 18.3% and 38.2% inhibition

Funalenone – 2.5 mg

Brand:
Cayman
CAS:
259728-61-5
Storage:
-20
UN-No:
Non-Hazardous - /

Funalenone is a phenalenone originally isolated from A. niger.{41696} It inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 μM) but is less cytotoxic to mammalian HPB-M(a) cells (IC50 = 87 μM).{41698} Funalenone selectively inhibits matrix metalloproteinase-1 (MMP-1; IC50 = 170 μM) over MMP-2 and MMP-9, which it inhibits by 18.3 and 38.2%, respectively, when used at a concentration of 400 μM.{41696} It also inhibits the bacterial cell wall synthesis enzymes MraY and MurG (IC50s = 25.5 μM in a membrane plate assay) and inhibits growth of S. aureus with a MIC value of 64 μg/mL.{41697}  

 

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SKU: 23491 - 2.5 mg Category:

Description

A phenalenone that inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 μM); less cytotoxic to HPB-M(a) cells (IC50 = 87 μM); selectively inhibits MMP-1 (IC50 = 170 μM) over MMP-2 and MMP-9 with 18.3% and 38.2% inhibition, respectively (400 μM); inhibits the bacterial cell wall synthesis enzymes MraY and MurG (IC50s = 25.5 μM); inhibits growth of S. aureus with a MIC value of 64 μg/mL

Formal name: 3,4,7,9-tetrahydroxy-2-methoxy-6-methyl-1H-phenalen-1-one

Synonyms: 

Molecular weight: 288.3

CAS: 259728-61-5

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antivirals|Integrase Inhibitors||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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