A mycotoxin; cytotoxic against a panel of seven rat hepatoma cell lines (IC50s = 3-50 µg/ml)

Fumonisin B2 – 500 µg

Brand:
Cayman
CAS:
116355-84-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Fumonisin B2 (FB2) is a mycotoxin that has been found in F. moniliforme.{1632} It is cytotoxic against a panel of seven rat hepatoma cell lines (IC50s = 3-50 µg/ml), as well as MDCK cells (IC50 = 2 µg/ml).{59489} FB2 (125-1,000 µM) is also cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 1,000 mg/kg for 21 days.{61109} FB2 has been detected in corn and corn-based foods and livestock feeds.{61110}  

 

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Description

A mycotoxin; cytotoxic against a panel of seven rat hepatoma cell lines (IC50s = 3-50 µg/ml), as well as MDCK cells (IC50 = 2 µg/ml); induces hepatocyte nodule formation in rats at 1,000 mg/kg; has been detected in corn and corn-based foods and livestock feeds

Formal name: 1,1′-[(1S,2R)-1-[(2S,9R,11S,12S)-12-amino-9,11-dihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl]ester-1,2,3-propanetricarboxylic acid

Synonyms:  FB2

Molecular weight: 705.8

CAS: 116355-84-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Cancer||Research Area|Toxicology|Cell Health & Viability||Research Area|Toxicology|Environmental|Agriculture

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