A mycotoxin; induces tremors in and is lethal to mice (LD50 = 5.4 mg/kg

Fumitremorgin B – 5 mg

Brand:
Cayman
CAS:
12626-17-4
Storage:
-20
UN-No:
Non-Hazardous - /

Fumitremorgin B is a mycotoxin originally isolated from A. fumigatus.{57187,57188} It induces tremors in and is lethal to mice (LD50 = 5.4 mg/kg, i.v.). It is also toxic to brine shrimp (LC50 = 13.6 μg/ml).{57189} Fumitremorgin B is active against the phytopathogenic fungi B. cinerea, A. solani, A. alternata, C. gloeosporioides, F. solani, F. oxysporum, and G. saubinettii (MICs = 6.25-100 μg/ml). It has antifeedant activity against armyworm (M. separata) larvae when applied to fresh wheat leaves. Fumitremorgin B inhibits the proliferation of U937 and PC3 cells (IC50s = 14.12 and 43.36 μM, respectively).{57190}  

 

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Description

A mycotoxin; induces tremors in and is lethal to mice (LD50 = 5.4 mg/kg, i.v.); toxic to brine shrimp (LC50 = 13.6 μg/ml); active against the phytopathogenic fungi B. cinerea, A. solani, A. alternata, C. gloeosporioides, F. solani, F. oxysporum, and G. saubinettii (MICs = 6.25-100 μg/ml); has antifeedant activity against armyworm (M. separata) larvae when applied to fresh wheat leaves; inhibits the proliferation of U937 and PC3 cells (IC50s = 14.12 and 43.36 μM, respectively)

Formal name: (5aR,6S,12S,14aS)-1,2,3,5a,6,11,12,14a-octahydro-5a,6-dihydroxy-9-methoxy-11-(3-methyl-2-buten-1-yl)-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1″,2″:4′,5′]pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-5,14-dione

Synonyms:  Lanosulin

Molecular weight: 479.6

CAS: 12626-17-4

Purity: ≥95%

Formulation: A solid

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