An antibiotic which inhibits MetAp2 with an IC50 value of 10 nM; inhibits angiogenesis by impairing the growth of endothelial cells; impairs microsporidial replication and can be used to treat microsporidial infections in immunocompromised patients; reduces diet-induced adipose tissue formation in mice

Fumagillin – 5 mg

Brand:
Cayman
CAS:
23110-15-8
Storage:
-20
UN-No:
Non-Hazardous - /

Fumagillin is an antibiotic derived from the fungus A. fumigatus. It binds and inhibits methionine aminopeptidase-2 with an IC50 value of 10 nM.{20540,20542} Fumagillin inhibits angiogenesis by impairing the growth of endothelial cells and altering gene expression.{20540,20543,20545} It also impairs microsporidial replication and can be used to treat both conjunctival and intestinal microsporidial infections in immunocompromised patients.{20539,20544} Finally, fumagillin reduces diet-induced adipose tissue formation in mice, independent of its effects on angiogenesis.{20541}  

 

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SKU: 11332 - 5 mg Category:

Description

An antibiotic which inhibits MetAp2 with an IC50 value of 10 nM; inhibits angiogenesis by impairing the growth of endothelial cells; impairs microsporidial replication and can be used to treat microsporidial infections in immunocompromised patients; reduces diet-induced adipose tissue formation in mice

Formal name: 2E,4E,6E,8E-decatetraenedioic acid, 1-[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl] ester

Synonyms:  Amebacilin|NSC 9168

Molecular weight: 458.6

CAS: 23110-15-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer|Angiogenesis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases

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