Description
A natural phytosterol with diverse biological activities including antioxidant, anti-inflammatory, anticancer, and antidiabetic properties among others; reduces the expression of TNF-α and IL-6 following LPS administration by halting NF-κB and p38 MAPK signaling in RAW 264.7 murine macrophages; decreases proliferation (IC50s = 185.4, 43.3, and 34.0 µg/ml, respectively, in HEK293, MCF-7, and SiHa cells); inhibits cell growth, halts the cell cycle at the G2/M transition, and induces apoptosis with maximally increased caspase-9, -8, and -3 expression at 68.8 µM; decreases serum glucose concentrations in a streptozotocin rat model of diabetes at 30 mg/kg,
Formal name: (3β,24E)-stigmasta-5,24(28)-dien-3-ol
Synonyms: trans-24-ethylidene Cholesterol
Molecular weight: 412.7
CAS: 17605-67-3
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Natural Products|Phytosterols||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Cell Signaling|p38 MAPK Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Plant Biology
