A natural phytosterol with diverse biological activities including antioxidant

Fucosterol – 1 mg

Brand:
Cayman
CAS:
17605-67-3
Storage:
-20
UN-No:
Non-Hazardous - /

Fucosterol is a plant sterol found in algae that has diverse biological activities including antioxidant, anti-inflammatory, anticancer, and antidiabetic properties among others.{36107} It decreases markers of oxidative damage and increases antioxidative enzyme activity in vitro.{36109} It reduces the expression of TNF-α and IL-6 following LPS administration by halting NF-κB and p38 MAPK signaling in RAW 264.7 murine macrophages.{36111} In HEK293, MCF-7, and SiHa cells, fucosterol decreases proliferation (IC50s = 185.4, 43.3, and 34.0 µg/ml, respectively).{36108} It also has anticancer activity in HL-60 leukemia cells, where it inhibits cell growth, halts the cell cycle at the G2/M transition, and induces apoptosis with maximally increased caspase-9, -8, and -3 expression at 68.8 µM.{36116} In a streptozotocin rat model of diabetes, it decreases serum glucose concentrations when administered at 30 mg/kg.{36110}  

 

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Description

A natural phytosterol with diverse biological activities including antioxidant, anti-inflammatory, anticancer, and antidiabetic properties among others; reduces the expression of TNF-α and IL-6 following LPS administration by halting NF-κB and p38 MAPK signaling in RAW 264.7 murine macrophages; decreases proliferation (IC50s = 185.4, 43.3, and 34.0 µg/ml, respectively, in HEK293, MCF-7, and SiHa cells); inhibits cell growth, halts the cell cycle at the G2/M transition, and induces apoptosis with maximally increased caspase-9, -8, and -3 expression at 68.8 µM; decreases serum glucose concentrations in a streptozotocin rat model of diabetes at 30 mg/kg,

Formal name: (3β,24E)-stigmasta-5,24(28)-dien-3-ol

Synonyms:  trans-24-ethylidene Cholesterol

Molecular weight: 412.7

CAS: 17605-67-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Natural Products|Phytosterols||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Cell Signaling|p38 MAPK Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Plant Biology

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