One of the stereoisomers of FTY720-phosphate that is apparently not formed in vivo; binds to S1P receptors with 5-130-fold lower affinity compared to FTY720 (S)-phosphate

FTY720 (R)-Phosphate – 5 mg

Brand:
Cayman
CAS:
402616-23-3
Storage:
-20
UN-No:
Non-Hazardous - /

FTY720 is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.{11265} FTY720 is phosphorylated by sphingosine kinases in vivo, and then acts as a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors.{11284} FTY720 (R)-phosphate is one of the stereoisomers of FTY720-phosphate, but it is apparently not formed in vivo.{17113} FTY720 (S)-phosphate exhibits Ki values of 2.1, 5.9, 23, and 2.2 nM for S1P1,3,4,5, respectively, whereas the R isomer binds with 5 to130-fold lower affinity.{17114}  

 

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SKU: 10006407 - 5 mg Category:

Description

One of the stereoisomers of FTY720-phosphate that is apparently not formed in vivo; binds to S1P receptors with 5-130-fold lower affinity compared to FTY720 (S)-phosphate

Formal name: (2R)-amino-2-[2-(4-octylphenyl)ethyl]-1-(dihydrogen phosphate)-1,3-propanediol

Synonyms: 

Molecular weight: 387.5

CAS: 402616-23-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Sphingolipids

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