A potent and selective FTase inhibitor (IC50 = 21 nM); greater than 30-fold selective for FTase over GGTase (IC50 = 790 nM); prevents farnesylation of Ras; inhibits proliferation of cells transformed by Ras farnesylation; reduces GTP-Ras

FTase Inhibitor I – 500 µg

Brand:
Cayman
CAS:
149759-96-6
Storage:
-20
UN-No:
Non-Hazardous - /

FTase inhibitor I is a potent inhibitor of farnesyltransferase (FTase; IC50 = 21 nM) that is greater than 30-fold selective for FTase over geranylgeranyl transferase (GGTase; IC50 = 790 nM).{38212} It prevents farnesylation of Ras and inhibits proliferation of cells transformed by Ras farnesylation.{38212,38211} In a dog model of subarachnoid hemorrhage, it reduces GTP-Ras in spastic basilar arteries, decreases angiographic vasospasm, and improves clinical scores.{38213}  

 

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Description

A potent and selective FTase inhibitor (IC50 = 21 nM); greater than 30-fold selective for FTase over GGTase (IC50 = 790 nM); prevents farnesylation of Ras; inhibits proliferation of cells transformed by Ras farnesylation; reduces GTP-Ras, decreases angiographic vasospasm, and improves clinical scores in a dog model of subarachnoid hemorrhage ,

Formal name: N-[(2S)-2-[[(2R)-2-amino-3-mercaptopropyl]amino]-3-methylbutyl]-L-phenylalanyl-L-methionine

Synonyms:  Farnesyltransferase Inhibitor I

Molecular weight: 470.7

CAS: 149759-96-6

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Signaling|GTPases||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke

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