A coumarin glycoside; inhibits formation of 5-HETE from arachidonic acid in rat polymorphonuclear leukocytes at 1-1

Fraxin – 50 mg

Brand:
Cayman
CAS:
524-30-1
Storage:
-20
UN-No:
Non-Hazardous - /

Fraxin is a coumarin glycoside that has been found in Fraxinus and has anti-inflammatory activity.{46396} It inhibits formation of 5-hydroxyeicosatetraenoic acid (5-HETE) from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in rat polymorphonuclear leukocytes when used at concentrations ranging from 1 to 1,000 µM in vitro.{46397} Fraxin inhibits production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells (IC50 = 84.5 µM).{46398} It also decreases LPS-induced TNF-α, IL-6, IL-1β, NF-ĸB, and NLRP3 expression in the lung in mouse models of acute lung injury and endotoxic shock when administered at doses ranging from 10 to 40 mg/kg.{46399,46400}  

 

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Description

A coumarin glycoside; inhibits formation of 5-HETE from arachidonic acid in rat polymorphonuclear leukocytes at 1-1,000 µM in vitro; inhibits production of NO in LPS-stimulated RAW 264.7 cells (IC50 = 84.5 µM); decreases LPS-induced TNF-α, IL-6, IL-1β, NF-ĸB, and NLRP3 expression in the lung in mouse models of acute lung injury and endotoxic shock at 10-40 mg/kg

Formal name: 8-(β-D-glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one

Synonyms:  Fraxetol 8-glucoside|Fraxoside

Molecular weight: 370.3

CAS: 524-30-1

Purity: ≥98%

Formulation: A crystalline solid

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