A coumarin with diverse biological activities; scavenges DPPH radicals

Fraxetin – 10 mg

Brand:
Cayman
CAS:
574-84-5
Storage:
-20
UN-No:
Non-Hazardous - /

Fraxetin is a coumarin that has been found in F. bungeana and has diverse biological activities.{51213,51214,51215} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals, ABTS (Item No. 27317) radicals, and hydrogen peroxide in cell-free assays (IC50s = 44.1, 37.4, and 40.5 μM, respectively).{51213} Fraxetin selectively reduces cell viability in a panel of six non-small cell lung cancer (NSCLC) cell lines (IC50s = 20.12-61.36 μM) over noncancerous cell lines (IC50s = >100 μM).{51214} Fraxetin (25 and 50 mg/kg) reduces levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (TBIL) in serum, decreases hepatic expression of TNF-α, IL-6, IL-1β, and COX-2, and attenuates hepatic fibrosis in a rat model of carbon tetrachloride-induced liver fibrosis.{51215}  

 

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SKU: 28011 - 10 mg Category:

Description

A coumarin with diverse biological activities; scavenges DPPH radicals, ABTS radicals, and hydrogen peroxide in cell-free assays (IC50s = 44.1, 37.4, and 40.5 μM, respectively); selectively reduces cell viability in a panel of six NSCLC cell lines (IC50s = 20.12-61.36 μM) over noncancerous cell lines (IC50s = >100 μM); reduces levels of AST, ALT, and TBIL in serum, decreases hepatic expression of TNF-α, IL-6, IL-1β, and COX-2, and attenuates hepatic fibrosis in a rat model of carbon tetrachloride-induced liver fibrosis at 25 and 50 mg/kg

Formal name: 7,8-dihydroxy-6-methoxy-2H-1-benzopyran-2-one

Synonyms:  7,8-Dihydroxy-6-Methoxycoumarin

Molecular weight: 208.2

CAS: 574-84-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Coumarins||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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