A selective PAK1 inhibitor that induces apoptosis in breast cancer cells and has been used to inhibit oncogenic KRAS signaling in non-small cell lung cancer cells

FRAX1036 – 10 mg

Brand:
Cayman
CAS:
1432908-05-8
Storage:
-20
UN-No:
Non-Hazardous - /

FRAX1036 is a selective inhibitor of p21-activated kinase 1 (PAK1), a serine/threonine kinase downstream of Rac1 and Cdc42 that is involved in tumorigenesis. It can induce apoptosis in breast cancer cells and has been shown to potentiate the activity of the microtubule stabilizing agent, docetaxel (Item No. 11637).{32879} Disruption of PAK1 via FRAX1036 has been used to inhibit oncogenic KRAS signaling in non-small cell lung cancer cells.{32878}  

 

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Description

A selective PAK1 inhibitor that induces apoptosis in breast cancer cells and has been used to inhibit oncogenic KRAS signaling in non-small cell lung cancer cells

Formal name: 6-[2-chloro-4-(6-methyl-2-pyrazinyl)phenyl]-8-ethyl-2-[[2-(1-methyl-4-piperidinyl)ethyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one

Synonyms: 

Molecular weight: 518.1

CAS: 1432908-05-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling

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