An inhibitor of LSF transactivation activity (IC50 = 2.1 µM); inhibits growth of NIH3T3

FQI 1 – 5 mg

Brand:
Cayman
CAS:
599151-35-6
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

FQI 1 is an inhibitor of Late SV40 Factor (LSF) transactivation activity (IC50 = 2.1 µM).{49248} It inhibits growth of NIH3T3, HeLa S3, and A549 cancer cells (GI50s = 3.8, 0.79, and 6.3 µM, respectively). FQI 1 decreases viability of QGY-7703 and Huh7 liver cancer cells, but not of non-cancerous Hc3716-hTERT cells and primary mouse hepatocytes, when used at a concentration of 4 µM.{49248,49249} It reduces tumor growth induced by N-nitrosodiethylamine (DEN) in mice and in a QGY-7703 hepatocellular carcinoma (HCC) mouse xenograft model when administered at doses of 4 and 1 mg/kg, respectively.  

 

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SKU: 23104 - 5 mg Category:

Description

An inhibitor of LSF transactivation activity (IC50 = 2.1 µM); inhibits growth of NIH3T3, HeLa S3, and A549 cancer cells (GI50s = 3.8, 0.79, and 6.3 µM, respectively); decreases viability of QGY-7703 and Huh7 liver cancer cells, but not of non-cancerous Hc3716-hTERT cells and primary mouse hepatocytes, at 4 µM; reduces tumor growth induced by DEN in mice and in a QGY-7703 HCC mouse xenograft model at 4 and 1 mg/kg, respectively

Formal name: 8-(2-ethoxyphenyl)-7,8-dihydro-1,3-dioxolo[4,5-g]quinolin-6(5H)-one

Synonyms:  Factor Quinolinone Inhibitor 1

Molecular weight: 311.3

CAS: 599151-35-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death||Research Area|Cancer|Transcription Factors

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