A high-affinity inhibitor of RAGE (Ki = 25 nM); blocks the binding of Aβ protein to RAGE and inhibits Aβ-induced cellular stress in RAGE-expressing cells; functional in mice when administered intraperitoneally and penetrates the BBB

FPS-ZM1 – 5 mg

Brand:
Cayman
CAS:
945714-67-0
Storage:
-20
UN-No:
De Minimis - 3077 / 9

FPS-ZM1 is a high-affinity inhibitor of the receptor for advanced glycation end products (RAGE; Ki = 25 nM).{21041} It blocks the binding of amyloid β (Aβ) protein to RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells.{21041} FPS-ZM1 is functional in mice when administered intraperitoneally and penetrates the blood-brain barrier (BBB), inhibiting β-secretase activity, Aβ production, microglia activation, and neuroinflammation.{21041,33327} FPS-ZM1 is used to elucidate the role of RAGE-mediated signaling in diverse physiological processes in vivo, including cancer tumor growth, angiogenesis, and metastasis, as well as BBB damage, edema, and inflammation after intracerebral hemorrhage.{33328,33329}  

 

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SKU: 11909 - 5 mg Category:

Description

A high-affinity inhibitor of RAGE (Ki = 25 nM); blocks the binding of Aβ protein to RAGE and inhibits Aβ-induced cellular stress in RAGE-expressing cells; functional in mice when administered intraperitoneally and penetrates the BBB

Formal name: 4-chloro-N-cyclohexyl-N-(phenylmethyl)-benzamide

Synonyms: 

Molecular weight: 327.9

CAS: 945714-67-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Cardiovascular System|Vasculature|Angiogenesis||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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