An inhibitor of PP2A and PP4 (IC50s = 3.2 and 3 nM

Fostriecin (sodium salt) – 500 µg

Brand:
Cayman
CAS:
87860-39-7
Storage:
-20
UN-No:
Non-Hazardous - /

Fostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively).{23816,23817} It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not inhibit PP2B.{23816,21678} Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation.{18481} On a related note, fostriecin was first identified as an antitumor antibiotic.{23815}  

 

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Description

An inhibitor of PP2A and PP4 (IC50s = 3.2 and 3 nM, respectively); less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not inhibit PP2B

Formal name: (6R)-5,6-dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraen-1-yl]-2H-pyran-2-one, monosodium salt

Synonyms:  Antibiotic CI-920|Phosphotrienin

Molecular weight: 452.4

CAS: 87860-39-7

Purity: ≥95%

Formulation: A powder

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Phosphorylated||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Epigenetics, Transcription, & Translation|Writers|Phosphorylation

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