A prodrug form of fosinoprilat; inhibits angiotensin I-induced pressor responses in normotensive rats

Fosinopril (sodium salt) – 50 mg

Brand:
Cayman
CAS:
88889-14-9
Storage:
-20
UN-No:
Non-Hazardous - /

Fosinopril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor fosinoprilat.{39303} Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril (2.5 mg/kg) reduces fractional shortening and decreases left ventricular size in a porcine model of congestive heart failure.{39770} Formulations containing fosinopril have been used in the treatment of hypertension and congestive heart failure.  

 

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Description

A prodrug form of fosinoprilat; inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys at 15, 15, and 10 µmol/kg, respectively; reduces fractional shortening and decreases left ventricular size in a porcine model of congestive heart failure at 2.5 mg/kg

Formal name: 4S-cyclohexyl-1-[2-[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline, monosodium salt

Synonyms:  SQ 28,555

Molecular weight: 585.7

CAS: 88889-14-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Angiotensin-converting Enzyme||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart||Research Area|Cardiovascular System|Vasculature|Vasodilation

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