A phenylethanoid glycoside; active against E. coli

Forsythoside A – 50 mg

Brand:
Cayman
CAS:
79916-77-1
Storage:
-20
UN-No:
Non-Hazardous - /

Forsythoside A is a phenylethanoid glycoside that has been found in F. suspensa and has diverse biological activities.{52386,52387,52388,52389} It is active against E. coli, P. aeruginosa, and S. aureus (MICs = 38.33, 38.33, and 76.67 µg/ml, respectively).{52386} Forsythoside A scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals with an EC50 value of 6.3 µg/ml. It reduces apoptosis induced by amyloid-β (25-35) (Aβ (25-35)) in PC12 cells when used at concentrations of 10 and 25 µM.{52388} Forsythoside A (15, 30, and 60 mg/kg per day) reduces increases in bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-6, and IL-1β and neutrophil and macrophage infiltration induced by cigarette smoke in a mouse model of chronic obstructive pulmonary disease (COPD).{52387} It decreases the latency mice take to find the platform in the Morris water maze in the SAMP8 model of rapid aging and dementia when administered at doses of 120 and 240 mg/kg per day.{52389}  

 

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SKU: 30110 - 50 mg Category:

Description

A phenylethanoid glycoside; active against E. coli, P. aeruginosa, and S. aureus (MICs = 38.33, 38.33, and 76.67 µg/ml, respectively); scavenges DPPH radicals (EC50 = 6.3 µg/ml); prevents Aβ (25-35)-induced apoptosis in PC12 cells at 10 and 25 µM; reduces cigarette smoke-induced increases in BALF levels of TNF-α, IL-6, and IL-1β and neutrophil and macrophage infiltration in a mouse model of COPD at 15, 30, and 60 mg/kg per day; decreases the latency mice take to find the platform in the Morris water maze in the SAMP8 model of rapid aging and dementia at 120 and 240 mg/kg per day

Formal name: 2-(3,4-dihydroxyphenyl)ethyl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-Glucopyranoside, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]

Synonyms:  Forsythiaside

Molecular weight: 624.6

CAS: 79916-77-1

Purity: ≥98%

Formulation: A crystalline solid

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