A broad-spectrum TK inhibitor that targets members of the HGF and VEGF receptor TK families

Foretinib – 10 mg

Brand:
Cayman
CAS:
849217-64-7
Storage:
-20
UN-No:
Non-Hazardous - /

Foretinib is a broad-spectrum tyrosine kinase (TK) inhibitor that targets members of the HGF and VEGF receptor TK families, as well as KIT, Flt-3, PDGFRβ, and Tie-2, at nanomolar concentrations.{32583,24156} It blocks HGF-induced Met phosphorylation and VEGF-induced ERK phosphorylation, preventing HGF-induced responses in tumor cells and HGV/VEGF-induced responses in endothelial cells.{32583,23657} Foretinib is functional in vivo, reducing tumor burden in an experimental model of lung metastasis.{32583}  

 

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Description

A broad-spectrum TK inhibitor that targets members of the HGF and VEGF receptor TK families, as well as KIT, Flt-3, PDGFRβ, and Tie-2, at nanomolar concentrations;reduces tumor burden in an experimental model of lung metastasis

Formal name: N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N’-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

Synonyms:  GSK1363089|XL880

Molecular weight: 632.7

CAS: 849217-64-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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