An inhibitor of PLA2 ( IC50 = 39 μM); inhibits release of arachidonic acid from rat polymorphonuclear leukocytes (IC50 = 24 μM); inhibits radioligand binding to L-type calcium channels in porcine heart membranes (IC50 = 0.39 μM)

Folipastatin – 2.5 mg

Brand:
Cayman
CAS:
139959-71-0
Storage:
-20
UN-No:
Non-Hazardous - /

Folipastatin is a fungal metabolite produced by A. unguis and an inhibitor of phospholipase A2 (PLA2; IC50 = 39 μM).{38997} It inhibits release of arachidonic acid (Item Nos. 90010 | 10006607) from rat polymorphonuclear leukocytes (IC50 = 24 μM). Folipistatin also inhibits radioligand binding to L-type calcium channels in porcine heart membranes (IC50 = 0.39 μM) but has no effect on contraction of taenia (IC50 = >100 μM).  

 

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SKU: 24924 - 2.5 mg Category:

Description

An inhibitor of PLA2 ( IC50 = 39 μM); inhibits release of arachidonic acid from rat polymorphonuclear leukocytes (IC50 = 24 μM); inhibits radioligand binding to L-type calcium channels in porcine heart membranes (IC50 = 0.39 μM)

Formal name: 3,8-dihydroxy-4,9-dimethyl-1,6-bis[(1Z)-1-methyl-1-propen-1-yl]-11H-dibenzo[b,e][1,4]dioxepin-11-one

Synonyms: 

Molecular weight: 380.4

CAS: 139959-71-0

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases

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