A selective serotonin reuptake inhibitor (Ki = 6.2 nM in rat hypothalamus) with comparatively little effect on noradrenaline reuptake (Ki = 1

Fluvoxamine (maleate) – 10 mg

Brand:
Cayman
CAS:
61718-82-9
Storage:
-20
UN-No:
Non-Hazardous - /

Fluvoxamine selectively inhibits the reuptake of serotonin (Ki = 6.2 nM in rat hypothalamus) with comparatively little effect on noradrenaline reuptake (Ki = 1,100 nM), resulting in decreased serotonin turnover in the brain.{25681,25680} By potentiating the pharmacological effects of serotonin and its precursor, 5-hydroxy tryptophan, in the central nervous system, fluvoxamine is known to exhibit antidepressant effects.{25680} At higher concentrations, fluvoxamine can block the activity of HERG channels (IC50 = 3.8 µM), which carry the delayed rectifier potassium current that is important for repolarization of ventricular action potentials over the course of normal cardiac functioning.{25679} It also has been reported to exhibit cardioprotective effects by stimulating the σ1 receptor.{25678}  

 

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Description

A selective serotonin reuptake inhibitor (Ki = 6.2 nM in rat hypothalamus) with comparatively little effect on noradrenaline reuptake (Ki = 1,100 nM); potentiates the pharmacological effects of serotonin and its precursor, 5-hydroxy tryptophan, in the CNS resulting in antidepressant effects

Formal name: (1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone O-(2-aminoethyl)oxime, 2Z-butenedioate

Synonyms:  Fevarin|Floxyfral|Luvox®|MK-264|NSC 309469

Molecular weight: 434.4

CAS: 61718-82-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Heart||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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