A synthetic glucocorticoid; selective for the glucocorticoid receptor over the mineralocorticoid

Fluticasone Furoate – 10 mg

Brand:
Cayman
CAS:
397864-44-7
Storage:
-20
UN-No:
Non-Hazardous - /

Fluticasone furoate is a synthetic glucocorticoid.{53493} It is selective for the glucocorticoid receptor over the mineralocorticoid, progesterone, and androgen receptors in reporter assays (EC50s = 0.03, 23.4, 0.9, and >10,000 nM, respectively), as well as estrogen receptor α (ERα) and ERβ in scintillation proximity assays (EC50s = >10,000 nM for both). Fluticasone furoate reduces LPS-induced increases in TNF-α production in human peripheral blood mononuclear cells (PBMCs) with an EC50 value of 0.12 nM. It decreases S. aureus enterotoxin-induced increases in IFN-γ, IL-2, IL-5, IL-17, and TNF-α levels in patient-derived nasal polyp tissue when used at a concentration of 100 nM.{53494} Intrathecal administration of fluticasone furoate (30 µg/animal) reduces ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in a rat model of allergic inflammation.{53493} Formulations containing fluticasone furoate have been used in the treatment of seasonal allergies.  

 

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SKU: 29878 - 10 mg Category:

Description

A synthetic glucocorticoid; selective for the glucocorticoid receptor over the mineralocorticoid, progesterone, and androgen receptors in reporter assays (EC50s = 0.03, 23.4, 0.9, and >10,000 nM, respectively), as well as ERα and ERβ in scintillation proximity assays (EC50s = >10,000 nM); reduces LPS-induced increases in TNF-α production in human PBMCs (EC50 = 0.12 nM); decreases S. aureus enterotoxin-induced increases in IFN-γ, IL-2, IL-5, IL-17, and TNF-α levels in patient-derived nasal polyp tissue in vitro at 100 nM; reduces ovalbumin-induced increases in BALF eosinophil infiltration in a rat model of allergic inflammation at 30 µg/animal intrathecally

Formal name: (6α,11β,16α,17α)-6,9-difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxo-androsta-1,4-diene-17-carbothioic acid, S-(fluoromethyl) ester

Synonyms:  GSK685698|GW 685698X

Molecular weight: 538.6

CAS: 397864-44-7

Purity: ≥98%

Formulation: A solid

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