An internal standard for the quantification of flurbiprofen by GC- or LC-MS

Flurbiprofen-d3 – 1 mg

Brand:
Cayman
CAS:
1185133-81-6
Storage:
-20
UN-No:
- 2811 / 6.1

Flurbiprofen-d3 is intended for use as an internal standard for the quantification of flurbiprofen (Item Nos. 70250 | 10004207 | 70255) by GC- or LC-MS. Flurbiprofen is a non-selective COX inhibitor (IC50s = 0.04 and 0.51 μM for COX-1 and COX-2, respectively).{1286} In vivo, flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats.{39761} Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg.{39762} Formulations containing flurbiprofen have been used to manage pain and inflammation associated with arthritis.  

 

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SKU: 25277 - 1 mg Category:

Description

An internal standard for the quantification of flurbiprofen by GC- or LC-MS

Formal name: 2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanoic-3,3,3-d3 acid

Synonyms: 

Molecular weight: 247.3

CAS: 1185133-81-6

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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