A PGF2α analog and prodrug form of (+)-fluprostenol; an FP receptor agonist (EC50 = 40.2 nM for induction of phosphoinositide turnover in HEK293 cells expressing the human ocular FP receptor); topical application induces miosis in conscious cats in a dose-dependent manner at 0.01

Fluprostenol isopropyl ester – 1 mg

Brand:
Cayman
CAS:
157283-68-6
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Fluprostenol isopropyl ester is an analog of prostaglandin F2α (PGF2α; Item Nos. 16010 | 16020) and an isopropyl ester prodrug form of (+)-fluprostenol (Item No. 16768).{8839,9613} Fluprostenol isopropyl ester is an FP receptor agonist, inducing phosphoinositide turnover in HEK293 cells expressing the human ocular FP receptor with an EC50 value of 40.2 nM.{11931} Topical application of fluprostenol isopropyl ester (0.01, 0.03, and 0.1 μg) induces miosis in conscious cats in a dose-dependent manner.{9613} It reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension when administered topically at doses of 0.1 and 0.3 μg twice per day. Formulations containing fluprostenol isopropyl ester have been used in the treatment of open-angle glaucoma and ocular hypertension.  

 

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Description

A PGF2α analog and prodrug form of (+)-fluprostenol; an FP receptor agonist (EC50 = 40.2 nM for induction of phosphoinositide turnover in HEK293 cells expressing the human ocular FP receptor); topical application induces miosis in conscious cats in a dose-dependent manner at 0.01, 0.03, and 0.1 μg; reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension when administered topically at 0.1 and 0.3 μg twice per day

Formal name: 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5Z-heptenoic acid, 1-methylethyl ester

Synonyms:  16-m-trifluoromethylphenoxy tetranor PGF2α isopropyl ester|AL-6221|Flu-Ipr|Travoprost

Molecular weight: 500.6

CAS: 157283-68-6

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Ophthalmology

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