An activator of Kv7/KCNQ; induces relaxation of preconstricted pulmonary arteries isolated from wild type and SERT+ mice; decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT+ mouse models of pulmonary arterial hypertension at 30 mg/kg per day; increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy at 10 mg/kg; increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine; indirectly antagonizes NMDA receptors via its effects on potassium channels

Flupirtine (maleate) – 50 mg

Brand:
Cayman
CAS:
75507-68-5
Storage:
-20
UN-No:
Non-Hazardous - /

Flupirtine is an activator of voltage-gated potassium channel 7 (Kv7/KCNQ).{45470,45471,45472} It induces relaxation of preconstricted pulmonary arteries isolated from wild-type and serotonin transporter-overexpressing (SERT+) mice.{45471} Flupirtine (30 mg/kg per day) decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT+ mouse models of pulmonary arterial hypertension. It increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy when administered at a dose of 10 mg/kg and increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine.{45472} Flupirtine also indirectly antagonizes NMDA receptors via its effects on potassium channels.{45470,45473}  

 

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An activator of Kv7/KCNQ; induces relaxation of preconstricted pulmonary arteries isolated from wild type and SERT+ mice; decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT+ mouse models of pulmonary arterial hypertension at 30 mg/kg per day; increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy at 10 mg/kg; increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine; indirectly antagonizes NMDA receptors via its effects on potassium channels

Formal name: N-[2-amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-carbamic acid, ethyl ester, 2Z-butenedioate

Synonyms: 

Molecular weight: 420.4

CAS: 75507-68-5

Purity: ≥95%

Formulation: A crystalline solid

Application||Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Pain Research

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