A synthetic corticosteroid that binds to the glucocorticoid receptor; prevents inflammation and epidermal cell proliferation; inhibits tumor promotion and DNA synthesis in mouse epidermis when applied topically at a dose of 10 µg/0.2 ml; an agonist at the Smo receptor (EC50 = 1

Fluocinonide – 5 mg

Brand:
Cayman
CAS:
356-12-7
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

Fluocinonide is a synthetic fluorinated corticosteroid that binds to the glucocorticoid receptor and has anti-inflammatory properties.{41241,41242} It prevents inflammation and epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014). Fluocinonide inhibits tumor promotion and DNA synthesis in mouse epidermis when applied topically at a dose of 10 µg/0.2 ml. It also acts as an agonist at the smoothened (Smo) receptor with an EC50 value of 1,000 nM in a ligand displacement assay in cells overexpressing the Smo receptor.{41243} Formulations containing fluocinonide are used in the treatment of various skin conditions, including psoriasis and atopic dermatitis.  

 

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SKU: 23803 - 5 mg Category:

Description

A synthetic corticosteroid that binds to the glucocorticoid receptor; prevents inflammation and epidermal cell proliferation; inhibits tumor promotion and DNA synthesis in mouse epidermis when applied topically at a dose of 10 µg/0.2 ml; an agonist at the Smo receptor (EC50 = 1,000 nM)

Formal name: 21-(acetyloxy)-6α,9-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione

Synonyms:  NSC 101791

Molecular weight: 494.5

CAS: 356-12-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation|Autoimmunity

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