A COX inhibitor (IC50s = 3.24 and 0.55 µM for COX-1 and COX-2

Flunixin (meglumine) – 250 mg

Brand:
Cayman
CAS:
42461-84-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Flunixin is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2 (IC50s = 3.24 and 0.55 µM, respectively).{48282} It inhibits carrageenan-induced prostaglandin E2 (PGE2; Item No. 14010) and thromboxane B2 (TXB2; Item No. 19030) production in sheep exudate and serum, respectively, when administered at a dose of 1.1 mg/kg.{48283} Flunixin (1.1 mg/I/kg) has anti-inflammatory, analgesic, and antipyretic activity in horses.{48284} Formulations containing flunixin have been used in the veterinary treatment of pain and fever in livestock.  

 

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SKU: 26644 - 250 mg Category:

Description

A COX inhibitor (IC50s = 3.24 and 0.55 µM for COX-1 and COX-2, respectively); inhibits carrageenan-induced PGE2 and TXB2 production in sheep exudate and serum, respectively, at 1.1 mg/kg; has anti-inflammatory, analgesic, and antipyretic activity in horses at 1.1 mg/I/kg

Formal name: 1-deoxy-1-(methylamino)-D-glucitol, 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylate

Synonyms:  NIH 10250

Molecular weight: 491.5

CAS: 42461-84-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Pain Research

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