An agonist of glucocorticoid and mineralocorticoid receptors (EC50s = 0.26 and 0.494 nM

Flumethasone – 100 mg

Brand:
Cayman
CAS:
2135-17-3
Storage:
-20
UN-No:
Non-Hazardous - /

Flumethasone is an agonist of glucocorticoid and mineralocorticoid receptors with EC50 values of 0.26 and 0.494 nM, respectively, in CV-1 cells expressing human receptors.{41565} In vitro, it inhibits the growth of UM-UC-3, TCC-SUP, and 5637 urothelial carcinoma cell lines at a concentration of 100 nM.{41566} Flumethasone (5 mg per animal) decreases tumor necrosis factor (TNF) production ex vivo in blood cells collected by bronchoalveolar lavage (BAL) from calves with experimentally-induced local lung inflammation.{41567} It also inhibits phytohemagglutinin-induced delayed hypersensitivity in calf skin. In vivo, flumethasone (5 μM) impairs cell cycle re-entry of cardiac cells seven days post cryo-injury to the heart and impairs cardiac regeneration in zebrafish.{41568}  

 

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SKU: 24184 - 100 mg Category:

Description

An agonist of glucocorticoid and mineralocorticoid receptors (EC50s = 0.26 and 0.494 nM, respectively, in CV-1 cells expressing human receptors); inhibits the growth of UM-UC-3, TCC-SUP, and 5637 urothelial carcinoma cell lines (100 nM); decreases TNF production ex vivo in blood cells collected by BAL from calves with experimentally-induced local lung inflammation (5 mg per animal); impairs cell cycle re-entry of cardiac cells seven days post cryo-injury to the heart and impairs cardiac regeneration in vivo in zebrafish (5 μM)

Formal name: 6α,9-difluoro-11β,17,21-trihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione

Synonyms:  NSC 5402|NSC 54702|U-10974

Molecular weight: 410.5

CAS: 2135-17-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer||Research Area|Cardiovascular System|Heart|Cardiogenesis||Research Area|Immunology & Inflammation

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