A cell-permeable

FLT3 Inhibitor – 50 mg

Brand:
Cayman
CAS:
301305-73-7
Storage:
-20
UN-No:
Non-Hazardous - /

Fms-like tyrosine kinase (FLT3) is a cell-surface receptor with important roles in stem cell development, hematopoiesis, and cancer.{29996,29997} FLT3 Inhibitor is a cell-permeable, ATP-competitive inhibitor of FLT3 (IC50 = 27 nM) that blocks the proliferation of myelomonocytic leukemia MV4-11 cells (IC50 = 0.41 µM).{29998} It is selective for FLT3 over a panel of 22 other kinases. FLT3 Inhibitor synergistically increases the cytotoxicity of an AF4-mimetic peptide against MV4-11 cells.{29995}  

 

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Description

A cell-permeable, ATP-competitive inhibitor of FLT3 (IC50 = 27 nM) that blocks the proliferation of myelomonocytic leukemia MV4-11 cells (IC50 = 0.41 µM)

Formal name: 2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxamide

Synonyms:  Fms-like Tyrosine Kinase Inhibitor|TCS 359

Molecular weight: 360.4

CAS: 301305-73-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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