A Notch signaling inhibitor (EC50 = 2.3 µM) that acts upstream of α-secretase and β-secretase cleavage; alters the maturation pattern of APP and prevents the shedding of APPs in HEK293 cells

FLI-06 – 5 mg

Brand:
Cayman
CAS:
313967-18-9
Storage:
-20
UN-No:
Non-Hazardous - /

FLI-06 is a first-of-its-kind inhibitor of Notch signaling (EC50 = 2.3 µM) that acts upstream of α-secretase and β-secretase cleavage.{33469} It disrupts the intracellular trafficking and processing of the Notch signaling pathway, inhibiting general secretion at a stage before exit from the endoplasmic reticulum (ER) and converting ER morphology from tubule to sheet.{33469} FLI-06 is reported to alter the maturation pattern of amyloid precursor protein (APP) and prevent the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid β.{33469}  

 

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Description

A Notch signaling inhibitor (EC50 = 2.3 µM) that acts upstream of α-secretase and β-secretase cleavage; alters the maturation pattern of APP and prevents the shedding of APPs in HEK293 cells

Formal name: 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid, cyclohexyl ester

Synonyms: 

Molecular weight: 438.5

CAS: 313967-18-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Cell Signaling|Notch Signaling||Research Area|Neuroscience

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