Blocks Cav1.2 channels and acts an antagonist of muscarinic acetylcholine receptors; inhibits contraction of detrusor myocytes and prevents activation of the micturition center in the brain

Flavoxate (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
3717-88-2
Storage:
-20
UN-No:
Non-Hazardous - /

Flavoxate blocks L-type calcium (Cav1.2) channels and acts an antagonist of muscarinic acetylcholine receptors. Through these actions, flavoxate inhibits contraction of detrusor myocytes and prevents activation of the micturition center in the brain, resulting in muscle relaxation (IC50 = 2 µM for relaxation of human bladder precontracted by K+).{30978} Flavoxate has been studied clinically for the management of overactive bladder, for its potential to relax urinary bladder smooth muscle in order to suppress the micturition reflex.{30978}  

 

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Description

Blocks Cav1.2 channels and acts an antagonist of muscarinic acetylcholine receptors; inhibits contraction of detrusor myocytes and prevents activation of the micturition center in the brain, resulting in muscle relaxation (IC50 = 2 µM for relaxation of human bladder precontracted by K+)

Formal name: 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 2-(1-piperidinyl)ethyl ester, monohydrochloride

Synonyms:  NSC 114649|Rec 7/0040

Molecular weight: 427.9

CAS: 3717-88-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience

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