A COX-2 inhibitor; inhibits LPS-induced TxB2 production (IC50 = 316 nM) in vitro; inhibits adjuvant-induced arthritis (ED50 = 0.29 mg/kg) in rats without causing gastrointestinal irritation; alleviates ischemia-repurfusion injury in canine liver and rat lung in vivo

FK-3311 – 1 mg

Brand:
Cayman
CAS:
116686-15-8
Storage:
-20
UN-No:
Non-Hazardous - /

FK3311 is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID).{39153,39154} FK3311 inhibits LPS-induced thromboxane B2 (TxB2; Item No. 19030) production (IC50 = 316 nM) in vitro and inhibits adjuvant-induced arthritis (ED50 = 0.29 mg/kg) in rats without causing gastrointestinal irritation. FK3311 also alleviates ischemia-repurfusion injury in canine liver and rat lung in vivo.{39155,39156}  

 

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Description

A COX-2 inhibitor; inhibits LPS-induced TxB2 production (IC50 = 316 nM) in vitro; inhibits adjuvant-induced arthritis (ED50 = 0.29 mg/kg) in rats without causing gastrointestinal irritation; alleviates ischemia-repurfusion injury in canine liver and rat lung in vivo,,

Formal name: N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]-methanesulfonamide

Synonyms:  COX-2 Inhibitor V

Molecular weight: 341.3

CAS: 116686-15-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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