An internal standard for the quantification of fingolimod by GC- or LC-MS

Fingolimod-d4 – 1 mg

Brand:
Cayman
CAS:
1346747-38-3
Storage:
-20
UN-No:
Non-Hazardous - /

Fingolimod-d4 is intended for use as an internal standard for the quantification of fingolimod (Item Nos. 11975 | 10006292) by GC- or LC-MS. Fingolimod is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb I. sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.{11265} Fingolimod is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5).{11284} Down-regulation of S1P1 receptors on T and B lymphocytes by fingolimod results in defective egress of these cells from spleen, lymph nodes, and Peyer’s patch.{11738} Fingolimod also enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C4 transporter Abcc1 and inhibits cytosolic phospholipase A2 activity.{11283,14604}  

 

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SKU: 25037 - 1 mg Category:

Description

An internal standard for the quantification of fingolimod by GC- or LC-MS

Formal name: 2-amino-2-(4-octylphenethyl)propane-1,1,3,3-d4-1,3-diol

Synonyms: 

Molecular weight: 311.5

CAS: 1346747-38-3

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Immunology & Inflammation|Adaptive Immunity

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