An inhibitor of 5α-reductase type II (IC50 = 4.2 nM); 100-fold selective for 5α-reductase type II over type I; does not affect the growth of androgen-refractory PC3 prostate cancer cells but increases the protein levels of Nrf2 and HO-1; decreases prostatic diameter and volume

Finasteride – 100 mg

Brand:
Cayman
CAS:
98319-26-7
Storage:
-20
UN-No:
Non-Hazardous - /

Finasteride is a 4-azasteroid competitive inhibitor of 5α-reductase type II (IC50 = 4.2 nM) and a derivative of testosterone.{23862} It is 100-fold selective for 5α-reductase type II over type I. Finasteride (10 µM) does not affect the growth of androgen-refractory PC3 prostate cancer cells but increases the protein levels of Nrf2 and heme oxygenase-1 (HO-1).{23866} It decreases prostatic diameter and volume, as well as dihydrotestosterone, but not testosterone, serum levels in dogs with spontaneous benign prostatic hypertrophy when administered at doses of 0.1 and 0.5 mg/kg.{48477} Finasteride reduces testosterone-induced type I procollagen and TGF-β1 protein levels in cultured human scalp dermal fibroblasts in a model of androgenic alopecia when applied at a concentration of 0.1 μM.{23865} Formulations containing finasteride have been used in the treatment of benign prostatic hyperplasia and androgenic alopecia in men.  

 

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Description

An inhibitor of 5α-reductase type II (IC50 = 4.2 nM); 100-fold selective for 5α-reductase type II over type I; does not affect the growth of androgen-refractory PC3 prostate cancer cells but increases the protein levels of Nrf2 and HO-1; decreases prostatic diameter and volume, as well as dihydrotestosterone serum levels in dogs with spontaneous benign prostatic hypertrophy at 0.1 and 0.5 mg/kg; reduces testosterone-induced type I procollagen and TGF-β1 protein levels in cultured human scalp dermal fibroblasts in a model of androgenic alopecia at 0.1 µM

Formal name: (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(1,1-dimethylethyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide

Synonyms:  MK-906

Molecular weight: 372.5

CAS: 98319-26-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Lipid Biochemistry|Sterol Lipids

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