An inducer of ferroptosis; induces ferroptosis in BJ cells overexpressing oncogenic HRASG12V via acetyl-CoA carboxylase-dependent reduction in expression of GPX4 protein; binds to and activates squalene synthase in a GPX4 degradation-independent manner

FIN56 – 10 mg

Brand:
Cayman
CAS:
1083162-61-1
Storage:
-20
UN-No:
Non-Hazardous - /

FIN56 is an inducer of ferroptosis and a derivative of CIL56 (Item No. 19287).{39186} It selectively induces ferroptosis in BJ cells overexpressing oncogenic HRASG12V via acetyl-CoA carboxylase-dependent reduction in expression of GPX4 protein. This effect is reversed by the ferroptosis inhibitors deferoxamine (Item No. 14595) and α-tocopherol as well as overexpression of the fusion protein GFP-GPX4. FIN56 also binds to and activates squalene synthase in a GPX4 degradation-independent manner.  

 

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SKU: 25180 - 10 mg Category:

Description

An inducer of ferroptosis; induces ferroptosis in BJ cells overexpressing oncogenic HRASG12V via acetyl-CoA carboxylase-dependent reduction in expression of GPX4 protein; binds to and activates squalene synthase in a GPX4 degradation-independent manner

Formal name: N2,N7-dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide

Synonyms: 

Molecular weight: 517.7

CAS: 1083162-61-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Cell Death|Ferroptosis

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