An active component of the filipin complex; reduces growth of various fungi (MICs = 1-10 μg/ml); inhibits ADP-stimulated respiration in rat liver mitochondria at 3.5 mg/ml; induces hemolysis of liposomes in a cholesterol-independent manner (IC50 = 0.5 μg/ml)

Filipin II – 2.5 mg

Brand:
Cayman
CAS:
38620-77-8
Storage:
-20
UN-No:
Non-Hazardous - /

Filipin II is a polyene and an active component of the polyene antibiotic filipin complex (Item No. 25073).{39829} It has broad-spectrum antifungal activity, reducing growth of various fungi, including B. dermatitidis, C. neoformans, and H. capsulatum (MICs = 1-10 μg/ml). Filipin II inhibits ADP-stimulated respiration in rat liver mitochondria when used at a concentration of 3.5 mg/ml.{39830} It also induces hemolysis of liposomes in a cholesterol-independent manner (IC50 = 0.5 μg/ml).{39831}  

 

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SKU: 25521 - 2.5 mg Category:

Description

An active component of the filipin complex; reduces growth of various fungi (MICs = 1-10 μg/ml); inhibits ADP-stimulated respiration in rat liver mitochondria at 3.5 mg/ml; induces hemolysis of liposomes in a cholesterol-independent manner (IC50 = 0.5 μg/ml),

Formal name: 4S,6S,8S,10R,12R,14R,16S,27S-octahydroxy-3R-hexyl-17,28R-dimethyl-oxacyclooctacosa-17E,19E,21E,23E,25E-pentaen-2-one

Synonyms: 

Molecular weight: 638.8

CAS: 38620-77-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antifungals|Polyenes||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases

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