An aldose reductase inhibitor (IC50 = 0.026 μM); inhibits AKR1B10 (IC50 = 33 μM); decreases sorbitol and myo-inositol levels in the sciatic nerves of STZ-induced diabetic rats (2 mg/kg per day); decreases nerve fiber abnormalities and reverses slowing of MNCV in an STZ-induced diabetic rat model of peripheral neuropathy (2 mg/kg per day); decreases the pain threshold in STZ-induced diabetic mice overexpressing human aldose reductase (4 mg/kg per day); decreases metastasis in a KM20 human colorectal cancer mouse xenograft model (50 mg/kg per day)

Fidarestat – 1 mg

Brand:
Cayman
CAS:
136087-85-9
Storage:
-20
UN-No:
- /

Fidarestat is an aldose reductase inhibitor (IC50 = 0.026 μM using human recombinant enzyme) that also inhibits aldo-keto reductase family 1 member B10 (AKR1B10; IC50 = 33 μM using human recombinant enzyme).{38790} It decreases sorbitol and myo-inositol levels in the sciatic nerve of rats with diabetes induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 2 mg/kg per day.{38791} Fidarestat (2 mg/kg per day) decreases nerve fiber abnormalities and reverses slowing of motor nerve conduction velocity (MNCV) in an STZ-induced diabetic rat model of peripheral neuropathy. It decreases the pain threshold in STZ-induced diabetic mice that overexpress human aldose reductase when administered at 4 mg/kg per day.{38792} Fidarestat (50 mg/kg per day) decreases metastasis in a KM20 human colorectal cancer mouse xenograft model.{38793}  

 

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Description

An aldose reductase inhibitor (IC50 = 0.026 μM); inhibits AKR1B10 (IC50 = 33 μM); decreases sorbitol and myo-inositol levels in the sciatic nerves of STZ-induced diabetic rats (2 mg/kg per day); decreases nerve fiber abnormalities and reverses slowing of MNCV in an STZ-induced diabetic rat model of peripheral neuropathy (2 mg/kg per day); decreases the pain threshold in STZ-induced diabetic mice overexpressing human aldose reductase (4 mg/kg per day); decreases metastasis in a KM20 human colorectal cancer mouse xenograft model (50 mg/kg per day)

Formal name: (2S,4S)-6-fluoro-2,3-dihydro-2′,5′-dioxo-spiro[4H-1-benzopyran-4,4′-imidazolidine]-2-carboxamide

Synonyms: 

Molecular weight: 279.2

CAS: 136087-85-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Neuroscience|Pain Research

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