A nucleoside analog with antiviral activity

Fialuridine – 5 mg

Brand:
Cayman
CAS:
69123-98-4
Storage:
-20
UN-No:
Non-Hazardous - /

Fialuridine (FIAU) is a nucleoside analog with antiviral activity. It inhibits thymidine kinases from herpes simplex virus types 1 and 2 with Ki values of 0.14 and 0.95 µM, respectively, while blocking green monkey Vero cell thymidine kinase less effectively (Ki = 53 µM).{26079} FIAU blocks DNA synthesis in human cytomegalovirus and hepatitis B, as well as herpes simplex.{26078,26080,26081} Notably, while FIAU has few adverse effects in several mammals, it causes mitochondrial toxicity leading to liver damage and death in humans.{26082}  

 

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Description

A nucleoside analog with antiviral activity, inhibiting thymidine kinases from herpes simplex virus types 1 and 2 with Ki values of 0.14 and 0.95 µM, while blocking green monkey Vero cell thymidine kinase less effectively (Ki = 53 µM)

Formal name: 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione

Synonyms:  5-Iodo-2’-Fluoroarauracil|FIAU|Fluoroiodoarauracil|NSC 678514

Molecular weight: 372.1

CAS: 69123-98-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Infectious Disease|Viral Diseases|HSV

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