An indoleacetamide that acts as a high affinity TSPO agonist (Ki = 5 nM); enhances steroidogenesis of neuroactive steroids

FGIN-1-27 – 5 mg

Brand:
Cayman
CAS:
142720-24-9
Storage:
-20
UN-No:
Non-Hazardous - /

FGIN-1-27 is an indoleacetamide that acts as a high affinity agonist of the 18 kDa translocator protein (TSPO; previously called the peripheral benzodiazepine receptor) with a Ki value of 5 nM.{30265} It can enhance steroidogenesis of neuroactive steroids such as allopregnanolone (Item No. 16930).{30265} Through this action, FGIN-1-27 indirectly potentiates GABAA receptor signaling to produce anticonvulsant, anxiolytic, and sedative activity in both animal and clinical models.{30265}  

 

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Description

An indoleacetamide that acts as a high affinity TSPO agonist (Ki = 5 nM); enhances steroidogenesis of neuroactive steroids, thus potentiating GABAA receptor signaling to produce anticonvulsant, anxiolytic, and sedative activity in both animal and clinical models

Formal name: 2-(4-fluorophenyl)-N,N-dihexyl-1H-indole-3-acetamide

Synonyms: 

Molecular weight: 436.6

CAS: 142720-24-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Neuroendocrinology||Research Area|Neuroscience|Seizure Disorders

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