An FGFR4 inhibitor (IC50 = 1.9 nM); inhibits proliferation of Huh7 cells (IC50 = 12 nM) induces bile acid synthesis in dogs

FGF401 – 5 mg

Brand:
Cayman
CAS:
1708971-55-4
Storage:
-20
UN-No:
Non-Hazardous - /

FGF401 is an inhibitor of FGF receptor 4 (FGFR4; IC50 = 1.9 nM).{43774} It inhibits proliferation of Huh7 carcinoma cells with an IC50 value of 12 nM. FGF401 induces bile acid synthesis in dogs, increasing plasma and fecal levels of bile acids when administered at a dose of 45 mg/kg per day for four weeks.{43775} It also decreases serum cholesterol when administered at doses ranging from 5 to 45 mg/kg per day.  

 

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SKU: 23029 - 5 mg Category:

Description

An FGFR4 inhibitor (IC50 = 1.9 nM); inhibits proliferation of Huh7 cells (IC50 = 12 nM) induces bile acid synthesis in dogs, increasing plasma and fecal levels of bile acids at 45 mg/kg per day for four weeks; decreases serum cholesterol at 5-45 mg/kg per day

Formal name: N-[5-cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-1,8-naphthyridine-1(2H)-carboxamide

Synonyms:  Roblitinib

Molecular weight: 506.6

CAS: 1708971-55-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|FGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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