A benzodiazepine receptor ligand with anxiogenic and proconvulsant properties; increases benzodiazepine receptor ligand binding and GABA-dependent chloride uptake in primary chick cerebral cortical neurons at 1 μM; decreases pinning of the other animal and increases avoiding behavior in rats at 5 mg/kg; reduces the infused PTZ seizure threshold and induces generalized seizures in mice when administered at doses of 10 and 40 mg/kg

FG-7142 – 50 mg

Brand:
Cayman
CAS:
78538-74-6
Storage:
-20
UN-No:
Non-Hazardous - /

FG-7142 is a benzodiazepine receptor ligand with anxiogenic and proconvulsant properties.{48712} It increases benzodiazepine receptor ligand binding and GABA-dependent chloride uptake in primary chick cerebral cortical neurons when used at a concentration of 1 μM. FG-7142 (5 mg/kg) decreases pinning of the other animal and increases avoiding behavior in rats, an effect that can be prevented by the benzodiazepine receptor antagonist Ro 15-1788 (flumazenil; Item No. 14252).{48713} It reduces the infused pentylenetetrazol (PTZ; Item No. 18682) seizure threshold and induces generalized seizures in mice when administered at doses of 10 and 40 mg/kg, respectively.{48714} FG-7142 (3.75, 7.5, and 15 mg/kg, i.p.) also decreases food and water intake, eating rate, and time spent in the open arms of the elevated plus maze in female rats.{48715}  

 

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Description

A benzodiazepine receptor ligand with anxiogenic and proconvulsant properties; increases benzodiazepine receptor ligand binding and GABA-dependent chloride uptake in primary chick cerebral cortical neurons at 1 μM; decreases pinning of the other animal and increases avoiding behavior in rats at 5 mg/kg; reduces the infused PTZ seizure threshold and induces generalized seizures in mice when administered at doses of 10 and 40 mg/kg, respectively; decreases food and water intake, eating rate, and time spent in the open arms of the elevated plus maze in female rats at 3.75, 7.5, and 15 mg/kg, i.p.

Formal name: N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide

Synonyms:  ZK 39106

Molecular weight: 225.2

CAS: 78538-74-6

Purity: ≥98%

Formulation: A crystalline solid

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