Description
G Protein-Coupled Receptor (GPR120) is a GPCR activated by the presence of long chain free fatty acids and is expressed in adipocytes and pro-inflammatory macrophages.{13205} The activation of GPR120 results in elevated Ca2+ and activation of the ERK cascade.{13205} ω-3 Fatty acid constituents such as DHA and EPA mediate GPR120 signaling resulting in inhibition of TLR and TNF-α inflammatory signaling pathways in a β-arrestin2/TAB1 dependent manner.{22326} The anti-inflammatory effects of GPR120 are indirectly involved in promoting insulin secretion and free fatty acid-induced inhibition of apoptosis.{13205} The predicted size for GPR120 is 42.2 kDa and the observed detection is approximately 43 kDa by Western blot.
Synonyms: Free Fatty Acid Receptor 4|G Protein-Coupled Receptor 120|GPCR129|GT01|O3FAR1|PGR4
Immunogen: Synthetic peptide from the C-terminal region of human FFAR4
Formulation: Peptide affinity-purified polyclonal antibody
Isotype:
Applications: ELISA, ICC, IHC, and WB
Origin:
Stability: 730 days
Application|ELISA||Application|Immunocytochemistry||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition
