Description
GPR41 is a G protein-coupled receptor activated by short chain fatty acids (SCFAs).{25541,25605,25606} Several SCFAs have the potential to bind and activate GPR41, with pentanoate being the most potent agonist.{25605} GPR41 couples through the Pertussis toxin-sensitive Gi/o family and its expression has been described in adipose tissue and the colonic lumen.{25606,25605,25541} The activation of GPR41 induces an increase in intracellular Ca2+, ERK1/2 activation and a decrease in intracellular cAMP.{25606,25605,25541} Activation of GPR41 may be involved in intestinal inflammation. The predicted size for GPR41 is 39 kDa. Cayman’s GPR41 (N-Term) Polyclonal Antibody detects a 43 kDa band by western blot in cell lysates.
Synonyms: Free Fatty Acid Receptor 3|G Protein-Coupled Receptor 41
Immunogen: Synthetic peptide from the N-terminal region of human GPR41
Formulation: 500 µl of peptide affinity-purified polyclonal antibody
Isotype:
Applications: FC, IF, and WB
Origin:
Stability: 365 days
Application|Flow Cytometry||Application|Immunofluorescence||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Immunology & Inflammation
