A plant-derived ester of a sesquiterpenic alcohol that acts as an agonist for ERα (IC50 = 33.1 nM) and an agonist/antagonist for ERβ (IC50 = 180.5 nM); demonstrates ionophorectic properties

Ferutinin – 5 mg

Brand:
Cayman
CAS:
41743-44-6
Storage:
-20
UN-No:
Non-Hazardous - /

Ferutinin is a plant-derived ester of a sesquiterpenic alcohol that acts as an agonist for estrogen receptor (ER) α (IC50 = 33.1 nM) and an agonist/antagonist for ERβ (IC50 = 180.5 nM).{26981} It also demonstrates ionophoretic properties, increasing calcium permeability of lipid bilayer membranes, mitochondria, thymocytes, sarcoplasmic reticulum, and liposomes at a concentration range of 1-50 µM.{26982,26983,26984} Ferutinin is cytotoxic to MCF-7 breast and TCC bladder cancer cells as well as human foreskin HFF3 fibroblasts (IC50s = 29, 24, and 36 µg/ml in vitro after 72 hours of exposure).{26983}  

 

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Description

A plant-derived ester of a sesquiterpenic alcohol that acts as an agonist for ERα (IC50 = 33.1 nM) and an agonist/antagonist for ERβ (IC50 = 180.5 nM); demonstrates ionophorectic properties, increasing calcium permeability of lipid bilayer membranes, mitochondria, thymocytes, sarcoplasmic reticulum, and liposomes at 1-50 µM

Formal name: 4-hydroxy-benzoic acid, (3R,3aS,4S,8aR)-1,2,3,3a,4,5,8,8a-octahydro-3-hydroxy-6,8a-dimethyl-3-(1-methylethyl)-4-azulenyl ester

Synonyms: 

Molecular weight: 358.5

CAS: 41743-44-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Death||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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