A lipophilic derivative of ferulic acid

Ferulic Acid ethyl ester – 10 g

Brand:
Cayman
CAS:
4046-02-0
Storage:
-20
UN-No:
Non-Hazardous - /

Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer.{1430,1420,19116,15917} Ferulic acid ethyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes.{21329} Ferulic acid ethyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC50 = 66.7 μM for ferulic acid ethyl ester vs. 44.6 μM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging).{21327} However, ferulic acid ethyl ester increases the expression of heme oxygenase-1, Hsp70, and Hsp72, providing neuroprotection against amyloid β-peptide.{21330,21328} Moreover, ferulic acid ethyl ester (25 μM) completely prevents cytotoxicity induced by ultraviolet B irradiation of normal human epidermal melanocytes, again associated with an induced expression of heme oxygenase-1 and Hsp70.{21326}  

 

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SKU: 11880 - 10 g Category:

Description

A lipophilic derivative of ferulic acid, with increased ability to cross cell membranes; less DPPH radical scavenging capacity than ferulic acid (IC50 = 66.7 μM for FAEE vs. 44.6 μM for ferulic acid); increases the expression of HO-1, Hsp70, and Hsp72, providing neuroprotection against amyloid β-peptide

Formal name: 3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid, ethyl ester

Synonyms:  BBR 3222|NSC 14879

Molecular weight: 222.2

CAS: 4046-02-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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