A hydroxamate siderophore produced by various fungi that facilitates iron chelation and uptake; can be utilized as a heterologous siderophore by bacteria including P. aeruginosa and V. parahaemolyticus; inhibits proliferation of murine spleen mononuclear cells induced by concanavalin A and reduces the number of concanavalin A-stimulated CD4+ T cells expressing the IL-2 receptor at 0.8 μM; inhibits heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner

Ferrichrome (iron-free) – 500 µg

Brand:
Cayman
CAS:
34787-28-5
Storage:
-20
UN-No:
Non-Hazardous - /

Ferrichrome is a hydroxamate siderophore produced by various fungi, including U. sphaerogena, that facilitates iron chelation and uptake by these organisms.{45053,45054,45055} It can be utilized as a heterologous siderophore by bacteria, including P. aeruginosa and V. parahaemolyticus.{45056,45057} Ferrichrome (0.8 μM) inhibits proliferation of murine spleen mononuclear cells induced by concanavalin A (Item No. 14951) and reduces the number of concanavalin A-stimulated CD4+ T cells expressing the IL-2 receptor.{45054} It also inhibits heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner.{45055}  

 

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Description

A hydroxamate siderophore produced by various fungi that facilitates iron chelation and uptake; can be utilized as a heterologous siderophore by bacteria including P. aeruginosa and V. parahaemolyticus; inhibits proliferation of murine spleen mononuclear cells induced by concanavalin A and reduces the number of concanavalin A-stimulated CD4+ T cells expressing the IL-2 receptor at 0.8 μM; inhibits heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner

Formal name: cyclo(glycylglycylglycyl-N5-acetyl-N5-hydroxy-L-ornithyl-N5-acetyl-N5-hydroxy-L-ornithyl-N5-acetyl-N5-hydroxy-L-ornithyl)

Synonyms:  Desferrichrome

Molecular weight: 687.7

CAS: 34787-28-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Metal Chelators||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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